The bill also designates more than 9 grams of a targeted methamphetamine precursor as a schedule Z illegal drug, but provides an affirmative defense if it is possessed for a legitimate medical purpose. The bill requires the Department of Health and Human Services, Office of Substance Abuse to create a Maine Meth Watch Program, based on a national so-called "Meth Watch" program, which helps deter suspicious sales and theft of precursor-containing medicines and other products used in the illegal manufacturing of methamphetamine.

The bill authorizes the Commissioner of Public Safety to adopt major substantive rules on further restrictions if the commissioner finds that certain circumstances pose a threat to the public health, safety and welfare.